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KMID : 1161520120160020121
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Animal Cells and Systems
2012 Volume.16 No. 2 p.121 ~ p.126
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Deformation prediction by a feed forward artificial neural network during mouse embryo micromanipulation
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Abbasi Ali A.
Vossoughi G. R.
Ahmadian M. T.
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Abstract
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In this study, a neural network (NN) modeling approach has been used to predict the mechanical and geometrical behaviors of mouse embryo cells. Two NN models have been implemented. In the first NN model dimple depth (w), dimple radius (a) and radius of the semi-circular curved surface of the cell (R) were used as inputs of the model while indentation force (f) was considered as output. In the second NN model, indentation force (f), dimple radius (a) and radius of the semi-circular curved surface of the cell (R) were considered as inputs of the model and dimple depth was predicted as the output of the model. In addition, sensitivity analysis has been carried out to investigate the influence of the significance of input parameters on the mechanical behavior of mouse embryos. Experimental data deduced by Fluckiger (2004) were collected to obtain training and test data for the NN. The results of these investigations show that the correlation values of the test and training data sets are between 0.9988 and 1.0000, and are in good agreement with the experimental observations.
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KEYWORD
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artificial neural network, biological cells, error back propagation algorithm, sensitivity analysis
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